European Journal of Medicinal Plants <p style="text-align: justify;"><strong>European Journal of Medicinal Plants (ISSN: 2231-0894)</strong> is dedicated to publish&nbsp;high quality papers (<a href="/index.php/EJMP/general-guideline-for-authors">Click here for Types of paper</a>)&nbsp;in all areas of medicinal plants research including plant growth and development, agronomic management, plant nutrition, plant physiology, cell biology, molecular biology, biotechnology, medicinal properties, phytochemical constituents, fitoterapia, pharmacognosy, essential oils, ehnopharmacology and phytomedicine. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> SCIENCEDOMAIN international en-US European Journal of Medicinal Plants 2231-0894 Anticancer Activity of Silver Nanoparticle by Using Cassia auriculata Extract <p>In this study, green synthesis of silver nanoparticles (Ag NPs) has done using traditional herbal namely <em>Cassia auriculata</em> extract by the simple Green synthesis method. The synthesized Ag nanoparticles were studied by the characterization techniques includes X-ray diffraction (XRD) crystallography for nature of crystalline with relevant parameters, Transmission electron microscopy (TEM) for particle size as well as the SAED patterns for amorphous, crystalline or polynanocrystalline and Photoluminescence analysis were carried out for the prepared NPs. Ag NPs were fabricated utilizing Phyto-aquatic extract of <em>Cassia auriculata</em> which act as a reducing agent, and it was converted into a precursor solution to coat on cotton fabrics for antibacterial applications. To further, its performance on anticancer application was studied for Michigan Cancer Foundation-7 (MCF-7) line breast cancer.</p> M. Prem Nawaz A. Afroos Banu S. Raja Mohamed M. Palanivelu A. Ayeshamariam ##submission.copyrightStatement## 2020-02-22 2020-02-22 1 9 10.9734/ejmp/2020/v31i230210 Evaluation of Antioxidant and Anti-Parkinson Activity of Portulaca oleracea Seed Methanolic Extract <p><strong>Aim:</strong> Evaluation of Antioxidant and Anti-Parkinson activity of <em>Portulaca oleracea</em> seed methanolic extract.</p> <p><strong>Place:</strong> C. U. Shah College of Pharmacy and Research, Wadhwan, Surendranagar, Gujarat, India.</p> <p><strong>Methodology: </strong>Collect plant materials were extracted with methanol. Extract was subjected to qualitative and quantitative investigation and antioxidant properties of extract was determine by Nitric oxide free radical scavenging activity and Reducing power by FeCl<sub>3</sub> method.</p> <p>Anti-Parkinson activity evaluated by two behavioral models namely, haloperidol induced catalepsy, and orofacial dyskinesia both models various behavioral activity/ parameter (catalepsy, vacuous chewing movement and tongue protrusion) were evaluated.</p> <p><strong>Results: </strong>Preliminary qualitative phytochemical screening was to reveal presence of polyphenols, flavanoids, glycoside, alkaloids, carbohydrates and reducing sugar etc. Based preliminary qualitative phytochemical screening; quantitative estimation of methanolic extract showed significant amount of polyphenols. <em>In-vitro</em> antioxidants was performed by two method reducing power by FeCl<sub>3</sub> and nitric oxide free radical scavenging, the methanolic extract shows significant antioxidant properties, based on polyphenols and antioxidant properties extracts was used for the Anti-Parkinson activity Haloperidol induced catalepsy in mice Treatment with <em>Portulaca oleracea</em> seed showed a significant (P&lt;0.01) reduction in the duration of cataleptic behavior dose dependently when compared to haloperidol treated group. Haloperidol induced orofacial dyskinesia in rat recovery of orofacial dyskinesia as evidenced by decrease in the frequency of vacuous chewing movement and tongue significant (P&lt;0.05) decrease in the frequency of vacuous chewing &amp; tongue protrusion while <em>Portulaca oleracea</em> seed (200 mg/kg) was found to be insignificant in this respect.</p> <p><strong>Conclusion: </strong>After <em>Portulaca oleracea </em>seed (MLPO) treatment, the significant alterations produced in Parkinson’s affected rodents in respect to lipid peroxidation and antioxidant concentration significantly contributing its antioxidant potential. This antiperoxide action observed in <em>Portulaca oleracea </em>seed (MLPO) treated animals might be due to the suppression of the production of reactive oxygen species. This compound may be found to scavenge free radicals, including hydroxyl anions and reduce the level of lipid peroxidation in MLPO animals. Inhibition of oxidative stress may be one of the possible mechanisms for the anti-Parkinson effects of <em>Portulaca oleracea </em>seed (MLPO).</p> Santosh Kumar Vaidya Dharmesh K. Golwala Darpini S. Patel Satyajit Sahoo ##submission.copyrightStatement## 2020-02-22 2020-02-22 10 17 10.9734/ejmp/2020/v31i230211 Antifungal Activity in Urginea indica Kunth. (Asparagaceae) <p>Aqueous extract of<em> Urginea indica kunth</em>. (Udupi acccession) was screened for antifungal activity against <em>Fusarium oxysporum, Sclerotium rolfsii, Magnaporthe orzae, Aspergillus flavus, Alternaria alternata, Aspergillus niger </em>and <em>Fusarium moniliformae </em>by poisoned food technique. The results confirmed <em>Urginea indica</em> extracts showed very significant antifungal activity against <em>Fusarium oxysporum</em> and showed significant inhibition for <em>Sclerotium rolfsii</em> and <em>Magnapothea orzaea</em> it showed no activity against <em>Aspergillus niger</em> and <em>Aspergillus flavus</em>. All the activity was evaluated to determine the lowest concentration required to inhibit visible mycelial growth of the pathogen at minmum concentration. <em>Fusarium oxysporum </em>showed very significant inhibition in 10% concentration (Reconfirmed) while <em>Sclerotium </em>showed significant inhibition in 25% concentration followed by<em> Magnoporthe oryzae</em>. The number of sclerotia spores formed was also reduced drastically. These results show that a potential and safe antifungal agent can be obtained from <em>Urginea</em>.</p> B. Mohana Shiva Kameshwari M. K. Prasana Kumar ##submission.copyrightStatement## 2020-02-26 2020-02-26 18 23 10.9734/ejmp/2020/v31i230212 Extraction of Phytochemical Compounds of Leea guineensis (G. Don) Leaves Using Non-polar and Polar Solvents <p><strong>Aims: </strong>Selection of a suitable solvent is important and utilized in the extraction of desirable chemical components in medicinal plants.</p> <p><strong>Study Design: </strong>Chemical analysis of various extracts of <em>Leea guineensis</em> leaves using standard analytical procedures.</p> <p><strong>Place and Duration of Study: </strong>Forestry Research Institute of Nigeria, between March 2019 and August 2019.</p> <p><strong>Methodology:</strong> Leaves of <em>Leea guineensis </em>were extracted with six solvents categorized into polar (Acetone, Methanol and Aqueous) and non-polar (Ethyl acetate, Hexane and Chloroform) types using cold maceration method, the qualitative and quantitative phytochemical assay was done on the respective extracts using the standard methods.</p> <p><strong>Results: </strong>Phytochemical screening of the non-polar solvent extract revealed the presence of flavonoids, alkaloids and saponins for all the solvents, while tannin was present only in ethyl acetate extract. For the polar solvent extracts, all the secondary metabolites determined were present except terpenoids and phlobatanins. In the quantitative test, alkaloid levels ranged from 1.31-38.25 mg/100 g, saponin: 2.01-14.35 mg/100 g, flavonoids: 1.10-6.25 mg/100 g, Tannin: ND-4.62 mg/100 g, terpenoids: ND-1.02 mg/100 g, cardiac glycosides: ND-0.84 mg/100 g, Anthraquinone: ND-2.58 mg/100 g and phlobatanins: ND-0.95. The results obtained for each of the phytochemicals are significantly different (p&lt;0.05) across all the solvent extracts, while phytochemicals such as terpenoids, cardiac glycosides, anthraquinones and phlobatanins were not detected in the non-polar solvent extract of <em>L. guineensis</em>.</p> <p><strong>Conclusion: </strong>The phytochemical constituents detected in varying quantities depend on the polarity of the substances, <em>L. guineensis</em> could be exploited and extracted very well using a polar solvent like methanol, acetone and aqueous.</p> O. L. Awotedu U. E. Okeke P. O. Ogunbamowo O. S Ariwoola T. O. Omolola ##submission.copyrightStatement## 2020-02-27 2020-02-27 24 31 10.9734/ejmp/2020/v31i230213 Antioxidant and Antimutagenic (Anticlastogenic) Activity of Alcoholic Extract of Bauhinia variegata (Linn.) Root <p><strong>Aims:</strong> Antioxidant and Antimutagenic (Anticlastogenic) activity of alcoholic extract of <em>Bauhinia variegata</em> (Linn.) root.</p> <p><strong>Place:</strong> C. U. Shah College of Pharmacy and Research, Wadhwan, Surendranagar, Gujarat, India.</p> <p><strong>Methodology</strong><strong>:</strong> Shade dried <em>Bauhinia variegata</em> (Linn.) root, extraction was carryout by isolation extract were subjected to primary and secondary Phytochemical investigation. Then <em>In-vitro</em> antioxidant properties were estimated by reducing power and nitric oxide free radical scavenging method. Based on Phytochemical constituent and antioxidant properties In-vivo Antimutagenic (Anticlastogenic) activity was performed.</p> <p><strong>Results:</strong> Preliminary phytochemical investigation revealed the presence of carbohydrates, free amino acids, and secondary metabolites like tannins, phenolic compounds and flavonoids, then polyphenol estimation found ALBV contains 86.38% phenolic compounds. In antioxidant properties determination IC50 respectively found 55.27±2.57 µg/ml, 125.52±8.15 µg/ml against of Ascorbic acid and Curcumin. Then <em>In-vivo</em> Antimutagenic (Anticlastogenic) activity ALBV shows significant reeducation in % MNPCE, % MNNCE and P/N ratio at 24 h, 48 h and 72 h against the cyclophosphamide-induced mutagenicity.</p> <p><strong>Conclusion: </strong>Therefore, from the present study, it is concluded that alcoholic extract of <em>Bauhinia variegata</em> root (ALBV) can prove to be a very good antioxidant and effective chemopreventive against cyclophosphamide-induced mutagenesis.</p> Dharmesh K. Golwala Santosh Kumar Vaidya Kishor K. Dholwani Darpini S. Patel Satyajit Sahoo ##submission.copyrightStatement## 2020-02-27 2020-02-27 32 39 10.9734/ejmp/2020/v31i230214