Effect of a Proprietary Arctostaphylous uva-ursi Standardized Extract (UvaZen-VArb™) on Melanin Regulation and Skin Applications- An In-silico Molecular Docking Study
Mihir Gadani
Department of Phytochemistry, Zeneherb Labs Pvt Ltd, Jogeshwari, Mumbai, Maharashtra, India.
Ratna Upadhyay
Department of Phytochemistry, Zeneherb Labs Pvt Ltd, Jogeshwari, Mumbai, Maharashtra, India.
Kavita Pandey *
Department of Bioanalytical Sciences (FYIC), GNIRD, G. N. Khalsa College, Matunga, Mumbai, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
Zenherb labs Pvt. Ltd., Mumbai, developed a proprietary Arctostaphylous uva-ursi standardized extract (AUSE), (branded as UvaZen-VArb™). The current study is an attempt to get insights of the interaction of bioactives against target proteins involved in skin health pathways like melanogenesis. A molecular docking approach was adopted to understand the protein-ligand interactions and predict the most probable mechanism(s) of beneficial skin health effects imparted by this cosmeceutical ingredient. Four phytoconstituents were docked against 15 shortlisted target proteins using Autodock Vina tool. Drug likeliness was assessed on the basis of ADMET properties and Lipinski’s Rule of 5. Arbutin, gallic acid, quercetin and rutin in AUSE demonstrated good docking scores and bioactivities for melanin regulation, cell growth, proliferation and differentiation-hair, skin and nail.
Keywords: Melanin regulation, Cosmeceuticals, skin lightening, dermatological effect, skin health, molecular docking, ADMET profiling