Anti-ulcerogenic Activity of Aqueous Extract of Unripe Fruit of Musa sapientum Linn in Combination with Vitamin C on Ulcer Induced Models in Experimental Rats
Moke Emuesiri Goodies *
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
Omorodion Lisa Iziegbe
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
Akpoguma Hitler Augustine
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
Imere Precious
Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria
Ahante Ejiroghene
Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Enugu State, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Aims: To evaluate the effect of aqueous extract of unripe fruit of Musa sapientum Linn in combination with Vitamin C on aspirin and ethanol induced ulcer models in Wistar rats.
Study Design: Anti-ulcer study.
Place and Duration of Study: Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria, between February and April, 2016.
Methodology: Forty-five rats divided into 9 groups of five were used for each model. Doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg of Musa sapientum (MS) alone and in combination with Vitamin C 100 mg/kg (1:1) were administered to the animals, Vitamin C 100 mg/kg was administered to another group, while the control group received distilled water. Omeprazole 20 mg/kg was given to a different group. The animals were sacrified and stomach was removed for examination.
Results: The aqueous extract of unripe fruit of Musa sapientum Linn showed significant (P<0.05) decrease in ulcer in both models, which was further enhanced by Vitamin C addition.
Conclusion: This study concludes that Vitamin C potentiates the anti-ulcerogenic effect of unripe fruits of Musa sapientum in rats.
Keywords: Ulcer, Musa sapientum, aspirin, ethanol, vitamin C