Gas Chromatography/Mass Spectrography (GC/MS) Analysis and Biological Properties of Probiotic Fermented Solenostemma argel
Sawsan M. El-Sonbaty *
Department of Radiation Microbiology, National Center of Radiation Research and Technology, Egypt
Somaya Z. Mansour
Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
El-Sayed M. E. Mahdy
Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt
Hatem A. El-Mezayen
Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt
Fatma Abdel-Fattah M. Salem
Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt
*Author to whom correspondence should be addressed.
Abstract
Solenostemma argel (S. argel) is an important medicinal plant in Egypt and Sudan, with antitumor effects. This study objective to elucidate the chemometric profile and antitumor properties of S. argel extract and the effect of fermentation on its properties. S. argel was fermented by two probiotic strains Lactobacillus rhamnosus and Lactobacillus acidophilus. While fermentation reduced total phenolics, and total flavonoid contents as well as DPPH radical scavenging activity, it enhanced antitumor activity on Ehrlich ascites carcinoma cell. The GC/MS analysis of fermented and non-fermented S. argel revealed the formation of new compounds of known antitumor activity.
Keywords: Solenostemma argel, probiotic fermentation, GC/MS, antitumor activity