Potential of Indonesian Herbal Medicine, Phaleria macrocarpa (Scheff.) Boerl, for Targeting Multiple Malignancy Signaling Pathways: An Introductory Overview
Ahmad Faried *
Department of Neurosurgery and Oncology Working Group, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Hendrikus Masang Ban Bolly
Department of Neurosurgery and Oncology Working Group, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia and Faculty of Medicine, Universitas Cendrawasih, Jayapura, Papua, Indonesia
Leri Septiani
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Dikdik Kurnia
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia
Muhammad Zafrullah Arifin
Department of Neurosurgery and Oncology Working Group, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Firman Fuad Wirakusumah
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
*Author to whom correspondence should be addressed.
Abstract
A wide variety of natural compounds have been recognized for targeting multiple malignancy signaling pathways and inducing apoptosis in various cancer cell lines from different origins. The chemical compositions of those substances present in plants contribute to their significant biological and medicinal value. In this review, we summarized our current findings and knowledge of bioactive compounds isolated from the Indonesian medicinal herb, Phaleria macrocarpa (Scheff.) Boerl, also known as Mahkota Dewa (MaDe) that originated from Papua province. A growing body of evidence from several countries suggests that the plant possesses potential for cancer therapy and chemoprevention. Exploring its mechanism in targeting multiple malignancy signaling pathways will provide valuable information for possible clinical applications in cancer management.
Keywords: Indonesian herb medicine, Phaleria macrocarpa, signaling pathways