Effect of Hydroalcoholic Extract of Some Medicinal Plants on Obesity
Majid Ramezani
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Saeed Changizi-Ashtiyani *
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran and Department of Physiology, Arak University of Medical Sciences, Arak, Iran
Firoozeh Sadeghzadeh
Department of Biology, Arak University of Medical Sciences, Arak, Iran
Seyed-Sirvan Hosseini
Student Research Committee, Arak University of Medical Sciences, Arak, Iran
Ali Zarei
Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran
Naser Hosseini
Department of Medicinal Plants, Arak University, Arak, Iran
*Author to whom correspondence should be addressed.
Abstract
Aims: Obesity is a significant cause of disability and death. This study was conducted to evaluate the efficacy of some medicinal plants in the treatment of obesity and its complications.
Study Design: Male Wistar rats were treated in different groups.
Place and Duration of Study: Department of Physiology, Arak University of Medical Sciences (Iran), December 2015 to July 2017.
Methodology: The groups were defined as the control, the high-fat diet and the high-fat diet with hydroalcoholic extracts of Camellia sinensis, Rosa canina, Althaea officinalis, Plantago major and Orlistat in their food, for 48 days. In the serum, the profiles of the liver enzymes and the thyroid hormones were measured as parameters of their appetite.
Results: The lowest increase in appetite happened in the Camellia sinensis group and the lowest levels of blood glucose and creatinine were in the Plantago primary group. The lowest cholesterol and low-density lipoprotein (LDL) were seen in the Camellia sinensis group (P<0.05). The amount of alanine aminotransferase (ALP) and the level of aspartate aminotransferase (AST) in the Plantago major group were significantly lower than the positive control group (P<0.05). In Althaea officinalis group were higher Orlistat and alkaline phosphatase (ALP) than the control group (P<0.05). The level of thyroid-stimulating hormone (TSH) in control group was significantly lower than the positive control, Camellia sinensis and Rosa canina groups (P<0.05). The level of thyroxin in Althaea officinalis, Rosa canina and Camellia sinensis groups were significantly lower than the positive control group, respectively (P<0.05).
Conclusion: Hydroalcoholic extracts of Camellia sinensis, Rosa canina, Althaea officinalis, and Plantago major are effective in reducing the damages caused by high-fat diet through decreasing lipid profiles, liver enzymes, without causing side effects on thyroid and renal functions.
Keywords: Obesity, Camellia sinensis, Althaea officinalis, Rosa canina, Plantago major