Casearia sylvestris Swartz Extract Release Using Natural Rubber Latex Biomembranes as Carrier
F. A. Borges
Department of Biological Sciences, School of Science and Letters of Assis, UNESP, Assis, Brazil
A. Trecco
Department of Biological Sciences, School of Science and Letters of Assis, UNESP, Assis, Brazil
N. R. Barros
Department of Biochemistry and Chemical Technology, Institute of Chemistry of Araraquara, UNESP, Araraquara, Brazil
M. C. R. Miranda
Department of Biochemistry and Chemical Technology, Institute of Chemistry of Araraquara, UNESP, Araraquara, Brazil
E. G. Pierri
Department of Natural Principles and Toxicology, School of Pharmaceutical Sciences, UNESP, Araraquara, Brazil
A. G. Santos
Department of Natural Principles and Toxicology, School of Pharmaceutical Sciences, UNESP, Araraquara, Brazil
R. D. Herculano *
Department of Biological Sciences, School of Science and Letters of Assis, UNESP, Assis, Brazil
*Author to whom correspondence should be addressed.
Abstract
The Natural Rubber Latex (NRL) from Hevea brasiliensis has shown promise in biomedical applications due to its low cost, easy handling, mechanical properties and biocompatibility, being used for bone regeneration and wound healing due to its natural stimulus to angiogenesis. The aim of this work was to incorporate Casearia sylvestris Sw. extract in NRL biomembranes and study its release behavior. The complex membrane-extract has as object of study a new approach of using C. sylvestris extract in the treatment of wounds, for possessing antiseptic activity, anti-inflammatory and analgesic properties. The C. sylvestris species (Salicaceae), popularly known as "guaçatonga", presents great distribution and is used in folk medicine as antiulcer, wound healing, anti-snake venom, properties which have been proven and related to clerodane diterpenes (casearins A-X). The release rate of C. sylvestris compounds from extract-membrane complex was monitored and analyzed using the method of optical spectroscopy (UV-VIS). The release varied with temperature ranging from 14 to 33 days, releasing more than 90%, with an interesting and promising biomedical application, such as wound healing and burns.
Keywords: Natural rubber latex, Casearia sylvestris, biomembrane, delivery system, casearin, Hevea brasiliensis