Protective Effect of Methanolic Extract of Hylocereus polyrhizus Fruits on Carbon Tetra Chloride-Induced Hepatotoxicity in Rat
Abu Mohammed Taufiqual Islam
Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwondo, Korea 200-701
Md. Ashraf Uddin Chowdhury
Department of Pharmacy, International Islamic University Chittagong, Bangladesh
Muhammad Erfan Uddin
Department of Pharmacy, International Islamic University Chittagong, Bangladesh
Md. Mominur Rahman
Department of Pharmacy, International Islamic University Chittagong, Bangladesh
Md. Razibul Habib
Superintendent of Drugs, Directorate General of Drug Administration, Bangladesh
Md. Golam Mezbah Uddin
Functional Food Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung 210-340, Korea
M. Atiar Rahman *
Department of Biochemistry & Molecular Biology, University of Chittagong, Chittagong-4331, Bangladesh
*Author to whom correspondence should be addressed.
Abstract
Aims: This research investigated the Protective effect of methanolic extract of Hylocereus Polyrhizus fruits on carbon tetra chloride-induced hepatotoxicity in Swiss-albino rat.
Place and Duration of Study: Department of Pharmacy, IIUC, Chittagong, Bangladesh and Functional Food Center, Korea Institute of Science and Technology (KIST), Gangneung Institute, Gangneung, Korea, between August 2011 to October, 2012.
Methodology: Hepatoprotective potential was evaluated in carbon tetrachloride (CCl4) induced liver injured animal model using male albino rats. Carbon tetrachloride significantly elevated the serum levels of biochemical markers like ALT, AST, ALP, bilirubin, total protein, total cholesterol, triglycerides.
Results: The methanolic extract of Hylocereus polyrhizus at a dose of 300 mg/kg body weight (p.o.) significantly protected the carbon tetrachloride (CCl4) induced liver toxicity in albino rat model. The activity of extract was also comparable to that of silymarin, a known hepatoprotective drug.
Conclusion: The study suggests that oral intake of Hylocereus polyrhizus fruits extract enhances the defense status against liver injury.
Keywords: Hylocereus polyrhizus, hepatoprotective, liver toxicity, silymarin