Green Combustion Synthesis of CeO2 and TiO2 Nanoparticles Doped with Same Oxide Materials of ZrO2: Investigation of in vitro Assay with Antibiotic Resistant Bacterium (ARB) and Anticancer Effect
A. Mohamed Saleem
Department of Physics, Jamal Mohamed College, Bharathidasan University, Thiruchirappalli, 620020, India.
S. Rajasekar
Department of Physics, Syed Ammal Engineering College, Ramanathapuram, 623503, India.
K. Kaviyarasu
UNESCO-UNISA Africa Chair in Nanoscience’s/Nanotechnology Laboratories, College of Graduate Studies, University of South Africa (UNISA), Muckleneuk Ridge, P.O.Box 392, Pretoria, South Africa and Nanosciences African Network (NANOAFNET), Materials Research Group (MRG), iThemba LABS-National Research Foundation (NRF), 1 Old Faure Road, 7129, P.O.Box 722, Somerset West, Western Cape, South Africa.
R. Perumalsamy
Department of Physics, Khadir Mohideen College, Affiliated to Bharathidasan University, Adirampattinam, Tiruchirappalli, 614701, India.
A. Ayeshamariam *
Department of Physics, Khadir Mohideen College, Affiliated to Bharathidasan University, Adirampattinam, Tiruchirappalli, 614701, India.
M. Jayachandran
Department of Physics, Sethu Institute of Technology, Pullor, Kariapatti, 621115, India.
*Author to whom correspondence should be addressed.
Abstract
This article reports the synthesis, characteristics and biomedical applications of CeO2-ZrO2 and TiO2-ZrO2 nanoparticles. The nanoparticles are synthesized by Green combustion method. Aloe Vera, dates and pomegranate extracts are used as mediators to avoid toxicity instead of chemical reagents. Hence it is biocompatible, non-toxic and avoiding adverse effect in biomedical applications. The nanoparticles are characterized by XRD to confirm the physical structure. The FTIR, Raman and SEM with EDAX analyses the chemical composition and their morphology. The antibacterial activity of these nanoparticles is assayed by well diffusion method against the bacterial pathogens of Stephylococcusaureus, Shigillaflexneri and Bacillus sp. The anticancer effect of the nanoparticles is investigated on A549 cell line by In Vitro assay. The conceivable purpose is the hydroxyl radicals which are easily produced by oxidizing more hydroxide ions in alkaline solution. Thus the competence of the development is rationally improved at pH is 9.
Keywords: Green combustion method, antimicrobial, biomedical applications, pathogens, cytotoxicity.