The Mitigating Effect of Jatropha curcas L. Latex against Genotoxicity Induced by Doxorubicin
Elisa Flávia Luiz Cardoso Bailão
Universidade Estadual de Goiás, Câmpus Henrique Santillo, Anápolis, GO, Brasil.
Illana Reis Pereira
Universidade Estadual de Goiás, Câmpus Ipameri, Ipameri, GO, Brasil.
Jeniffer Gabrielle Vieira Silva
Universidade Estadual de Goiás, Câmpus Henrique Santillo, Anápolis, GO, Brasil.
Maria Alice Montes de Sousa
Pontifícia Universidade Católica de Goiás - PUC, Goiânia, GO, Brasil.
Fábio Santos Matos
Universidade Estadual de Goiás, Câmpus Ipameri, Ipameri, GO, Brasil.
Leonardo Luiz Borges
Universidade Estadual de Goiás, Câmpus Henrique Santillo, Anápolis, GO, Brasil and Pontifícia Universidade Católica de Goiás - PUC, Goiânia, GO, Brasil.
Pablo José Gonçalves
Instituto de Física da Universidade Federal de Goiás, UFG, Goiânia, GO, Brasil.
Paulo Roberto de Melo-Reis
Pontifícia Universidade Católica de Goiás - PUC, Goiânia, GO, Brasil.
Luciane Madureira Almeida *
Universidade Estadual de Goiás, Câmpus Henrique Santillo, Anápolis, GO, Brasil.
*Author to whom correspondence should be addressed.
Abstract
Jatropha curcas (Euphorbiaceae) is a multiple purpose lacticiferous plant with potential for biodiesel production and medicinal uses. There is in the literature different analyses about the toxic and cytogenotoxic effects of J. curcas extracts, but few information about latex toxicity. In addition, few models were employed to evaluate the toxicity response to J. curcas latex, and the toxicity in in vivo mammal’s model has not been tested yet. The cytotoxic, mutagenic and antimutagenic potential of J. curcas latex were investigated using mouse bone marrow erythrocytes. The results indicated a cytotoxic and mutagenic potential of this latex to mammalian cells. But, when J. curcas latex was co-administrated with doxorubicin (DXR – chemotherapy medication), a reduction in the number of micronuclei was observed, indicating an interaction between J. curcas latex and DXR. The interaction of latex with DXR can cause a reduction in the activity of this drug and impair the treatment of its users. Moreover, there is a lack of data on herb–drug interactions, what should be more investigated to safeguard the wellbeing of patients.
Keywords: Doxorubicin, herb-drug interactions, micronucleus, mouse bone marrow erythrocytes, plant polyphenols.