Anticancer Efficacy of Thevetia peruviana (Pers.) K. Schum. Extracts on Triple Negative Human Breast Cancer Cell Line
S. Rajhans *
Department of Botany, Bioinformatics and Climate Change Impacts Management, Gujarat University, Ahmedabad, Gujarat, India.
K. Bhadresha
Department of Lifesciences, Gujarat University, Ahmedabad, Gujarat, India.
D. K. Yadav
Department of Lifesciences, Gujarat University, Ahmedabad, Gujarat, India.
R. M. Rawal
Department of Lifesciences, Gujarat University, Ahmedabad, Gujarat, India.
H. A. Pandya
Department of Botany, Bioinformatics and Climate Change Impacts Management, Gujarat University, Ahmedabad, Gujarat, India.
A. U. Mankad
Department of Botany, Bioinformatics and Climate Change Impacts Management, Gujarat University, Ahmedabad, Gujarat, India.
*Author to whom correspondence should be addressed.
Abstract
In this 21st century cancer has become the second big reason for death next to heart attack in both developed and the developing countries. Worldwide, there are almost 2.1 million newly diagnosed breast cancer cases in 2018, accounting for 1 in 4 cancer cases among women. Triple Negative Human Breast Cancer is one of the types of human breast cancer. The plant extracts of Thevetia peruviana (Pers.) K. Schum. has been used against the Triple Negative Human Breast Cancer cell line MDA-MB-231 for the current experiment All the 5 parts (leaf, stem, flower, fruit and seed) had been selected for the experiment and the extracts of the various parts were made in hydro-alcoholic solvent i.e. methanol: Water.
Keywords: Thevetia peruviana (Pers.) K. Schum, triple negative human breast cancer, MDA-MB-231, plant parts, soxhlet extraction.