In silico Analysis of Phytochemicals from Cocoa against Ribitol-5-Phosphate 2-Dehydrogenase of Streptococcus pneumoniae Causing Pneumonia
Sunanya Das
Centurion University of Technology and Management, Odisha, India.
Suchismita Khatei
Centurion University of Technology and Management, Odisha, India.
Saismita Sahoo
Centurion University of Technology and Management, Odisha, India.
Sitaram Swain
Centurion University of Technology and Management, Odisha, India.
Dipankar Bhattacharyay *
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
This analysis aims at evaluating the effects of Cocoa extract on Pneumonia. Pneumonia is caused by Streptococcus pneumoniae. Caffeine, Chorogenic acid, Ferulic acid, Iso- Orientin, luteolin, Naringenin and Vanillic acid of Cocoa were interacted with ribitol-5-phosphate 2-dehydrogenase which is involved in pentose and glucorunate interconversion pathways of Streptococcus pneumoniae. The enzyme was taken as receptor and phytochemicals were considered as ligands. All the interactions were done in Biovia discovery Studio 2020 and the process is known as molecular Docking. Molecular Docking provides us an opportunity to identify the potential phytochemical or component which can act as powerful tool against the pathogen. Out of all the phytochemicals, Luteolin of Cocoa inhibits or blocks the mechanism or action of ribitol-5-phosphate 2-dehydrogenase enzyme of Streptococcus pneumoniae. There is high possibility that these phytochemicals can potentially inhibit others enzymes involved in various metabolic pathways of Streptococcus pneumoniae.
Keywords: Phytochemical, biovia discovery studio 2020, cocoa, metabolic pathways, pneumonia, Streptococcus pneumonia.