The Effect of Ginger on the Invasion and Migration of Glioma Cells
Manar Zraikat *
Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.
Munir Gharaibeh
Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.
Tasneem Alshelleh
Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.
*Author to whom correspondence should be addressed.
Abstract
Background: This work studies the effect of different concentrations of soaked ginger on the ability of the U87 glioma cells to invade collagen in a three dimension (3 D) invasion model and compare it with its effect on the ability of the same cell line to migrate in two-dimension (2 D) scratch assay.
Methods: The hanging drop spheroids in 3D invasion assay were used to investigate the in invasion of the U87 cells. The 2D scratch assay was used to investigate the migration of the same cell line.
Results: Gradual effect of the soaked ginger was noticed on the inhibition of the invasion of U87 in collagen and on the inhibition of the migration of the same cell line in scratch assay.
Conclusion: The results in this article are promising and encourage further studies to investigate the effect of ginger active ingredients on tumour progression.
Keywords: Invasion, cancer, migration, assay